GHK-Cu

GHK-Cu is a naturally occurring copper-binding tripeptide found in human blood and tissue. 'Copper peptide' is its common shorthand. It was first identified in human plasma and has been studied extensively for its effects on wound healing, collagen synthesis, and skin remodeling. In the body, GHK-Cu levels decline with age - this is part of why it is considered relevant to both cosmetic and longevity applications. The mechanism centers on stimulation of collagen production, which underpins both skin structure and wound repair. GHK-Cu also appears to support follicle activity, which is why it has a strong secondary role in hair regrowth alongside its primary application in skin and anti-aging. GHK-Cu is one of the few peptides with strong clinical evidence (the highest of the three evidence tiers used here), reflecting decades of research on topical copper peptide formulations as well as injectable studies. It can be delivered two ways: as a topical serum applied to the skin, or as a subcutaneous injection at 1 to 2 mg. Topical is the more common and accessible route - topical copper peptide serums are widely sold. The injectable form is compounded and tends to be used when stronger systemic effects are desired. Both routes are used on a daily basis, in the evening. Cycle length is 8 to 12 weeks. Topical GHK-Cu is very gentle and well tolerated. The injectable form can cause stinging at the injection site. No pregnancy or cancer-history contraindications are listed for GHK-Cu. It stacks well with BPC-157, TB-500 (in healing protocols), and SNAP-8 (in cosmetic skin protocols). Exact route of administration, dosing, and cycle structure are determined with a licensed provider in the PepDepo network at consult.