NAD+

NAD+ (Nicotinamide adenine dinucleotide) is a coenzyme found in every cell of the body. It plays a central role in two critical processes: mitochondrial energy production and DNA repair. Levels of NAD+ decline with age, and that decline is associated with reduced cellular efficiency and resilience. The mechanism is foundational - NAD+ is not a signaling molecule that activates a specific receptor; it is a metabolic cofactor that mitochondria depend on to produce ATP, the cell's main energy currency. Restoring NAD+ levels is intended to support that underlying energy infrastructure. Primary goals are energy support and longevity, with cognition as a meaningful secondary aim. People drawn to NAD+ include those building broad longevity protocols, those experiencing age-related fatigue or cognitive fog, and those stacking it alongside other mitochondrial compounds. It is taken by subcutaneous injection or intravenously (IV). For subcutaneous use, the dose range is 50 to 100 mg. Frequency is several times per week, timed to the morning. Cycles can be ongoing or cyclical depending on the protocol. The main safety note is important: injecting too quickly causes flushing and chest tightness. The standard guidance is to go slow on injection rate. This applies particularly to IV administration. NAD+ stacks well with MOTS-c, SS-31, and 5-Amino-1MQ for broader mitochondrial and metabolic support. There are no contraindications based on pregnancy or cancer history. NAD+ is compounded by licensed pharmacies. Exact dosing is set with a licensed provider in the PepDepo network at consult.