Sermorelin

Sermorelin is a synthetic analog of growth hormone-releasing hormone (GHRH), specifically the first 29 amino acids of the naturally occurring molecule. It works by telling your own pituitary gland to release growth hormone in natural pulses - meaning your body keeps control of when and how much it produces, rather than receiving GH from an outside source. This makes it one of the gentler entry points into GH-axis support. It tends to be used by people focused on recovery from training or injury, building or preserving lean muscle, improving sleep quality, and supporting overall longevity. Fat loss is a secondary benefit rather than its main draw. Sermorelin is given as a subcutaneous injection, typically before bed on an empty stomach, five nights on and two nights off per week. Doses generally fall in the 100-300 mcg range, though your exact amount is set at consult based on your profile and goals. A typical course runs three to six months, after which your clinician will reassess whether to continue, adjust, or pause. On the safety side, the most common reactions are mild flushing or local irritation at the injection site. Because sermorelin stimulates the GH axis, it is not appropriate for anyone with a cancer history - this is a firm contraindication. In the US, it is available through licensed compounding pharmacies and has a solid clinical track record. Sermorelin stacks well with ipamorelin or CJC-1295 (no DAC) if a stronger combined effect is desired, though it is generally not run alongside MK-677. Your licensed provider in the PepDepo network will determine the exact dose and any combination that fits your situation at the time of your consult.