Protocol · Build muscle / Lose fat

Recomp

Lose fat and build lean muscle at the same time.

In this protocol

Overview

Recomp is for body recomposition - losing fat and building lean muscle at the same time. Most approaches treat these as separate phases. This stack works on both simultaneously using CJC-1295, Ipamorelin, and MOTS-c. CJC-1295 (no DAC, also called Mod GRF 1-29) is a GHRH analog that increases the size of each natural GH pulse without disrupting your body's own rhythm. It's almost always paired with Ipamorelin because the two act through related but distinct pathways - CJC amplifies the pulse, Ipamorelin triggers it selectively without raising cortisol or hunger. The combined GH environment supports muscle protein synthesis and fat oxidation at the same time. These two are the foundation of recomposition peptide protocols, and they're well-established in clinical compounding. MOTS-c brings a different dimension. It's a mitochondrial-derived peptide that improves insulin sensitivity and metabolic flexibility - essentially, how readily your body switches between burning carbohydrates and burning fat. It has been described as mimicking the metabolic effects of exercise at the cellular level. Dosed a few mornings per week, it sharpens energy utilization in a way that supports both training performance and fat loss. The schedule keeps everything in its optimal window. CJC-1295 and Ipamorelin go nightly before bed, on an empty stomach. MOTS-c is taken 2 to 3 mornings per week. The Recomp stack runs for 3 to 6 months for the GH pair, with MOTS-c cycled in 4 to 8 week periods. Exact dosing, timing relative to training, and cycle structure are set with a licensed provider in the PepDepo network at your consult.

How it runs

CJC-1295 + Ipamorelin nightly; MOTS-c 2-3x per week in the morning.

The CJC/Ipamorelin pair raises GH for body recomposition while MOTS-c sharpens metabolic flexibility and energy.

Questions

Can I really lose fat and gain muscle at the same time?⌄

True body recomposition is possible, especially for people with room to optimize their GH axis and metabolic flexibility. The stack doesn't promise a specific outcome - it supports the hormonal and cellular environment where both processes can happen together. Results vary based on training, nutrition, and individual physiology.

How do I run this stack day to day?⌄

CJC-1295 and Ipamorelin are injected subcutaneously each night before bed on an empty stomach. MOTS-c is injected subcutaneously 2 to 3 mornings per week. Eating close to the nightly injections can blunt the GH pulse, so timing matters.

Why is CJC-1295 without DAC used here and not the DAC version?⌄

CJC-1295 without DAC preserves your natural GH pulse pattern, which is generally preferred for recomposition. The DAC version raises the GH baseline more steadily - a different profile. The no-DAC form is almost always paired with Ipamorelin for this reason.

What does MOTS-c actually do?⌄

MOTS-c is a mitochondrial-derived peptide that improves insulin sensitivity and metabolic flexibility - how efficiently your cells use energy and switch fuel sources. It supports fat metabolism and energy in a way that complements the GH-driven effects of the CJC/Ipamorelin pair.

How long is the protocol?⌄

CJC-1295 and Ipamorelin are generally run for 3 to 6 months. MOTS-c cycles run 4 to 8 weeks. Your clinician will set the exact structure based on your goals and response.

Are there people who should not use this stack?⌄

People with a history of cancer should not use CJC-1295 or Ipamorelin, which are GH-stimulating peptides. MOTS-c is well tolerated with no listed exclusions. Your health history is reviewed at consult before any protocol is started.

Do I need to be training to get benefit from this stack?⌄

The stack data doesn't prescribe a training requirement, but recomposition outcomes - gaining muscle while losing fat - are driven by both the peptide protocol and physical training. Your clinician will help you understand what conditions the protocol is most likely to support.

Run this protocol safely

A licensed provider in the PepDepo network sets your exact protocol and dosing.

Book a consult

Education only, not medical advice. Peptides discussed are for informational purposes and many are not FDA-approved. Eligibility, prescribing, compounding, and dispensing are handled by appropriately licensed entities. Exact protocols and dosing are set with a licensed provider in the PepDepo network at consult. Content is pending clinical review.