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Immune / anti-inflammatory

VIP

Also known as Vasoactive Intestinal Peptide

Intranasal peptide used in chronic inflammation and CIRS protocols.

Emerging evidence

Overview

VIP, short for Vasoactive Intestinal Peptide, is a naturally occurring signaling peptide found throughout the nervous system and the gut. As a therapeutic compound it is used primarily in protocols targeting chronic inflammation, immune dysregulation, and conditions related to biotoxin illness, including CIRS (chronic inflammatory response syndrome). How it works: VIP acts as a regulatory signaling molecule that modulates immune balance, controls inflammatory pathways, and influences blood flow. It helps the body calibrate its inflammatory response rather than suppressing it bluntly. Who tends to use it: VIP protocols are most commonly associated with people dealing with chronic immune dysfunction and inflammatory conditions, particularly those being treated under specialized CIRS protocols. It also has supporting applications for gut function and cognitive symptoms. Its primary goal weight is immune support, with gut health and cognition as secondary targets. What to expect: VIP is not a short-cycle peptide. It is used in longer, closely monitored protocols because its effects on immune regulation require sustained use and regular assessment by the clinician overseeing the protocol. How it is taken: VIP is administered intranasally - as a nasal spray, not an injection. The dose is 50 mcg per spray, taken as several sprays daily. The precise timing and number of sprays per day are set by the protocol. Blood pressure is monitored during VIP use. Safety notes: Blood pressure monitoring is a requirement during VIP protocols. It is a compounded preparation. There are no exclusion flags for pregnancy or cancer history in the current record, but it is used specifically within specialized clinical protocols rather than as a general wellness peptide. Exact protocol structure, spray count, and monitoring plan are established with a licensed provider in the PepDepo network before starting.

At a glance

Route
Intranasal
Dose
50 mcg per spray
Frequency
Several sprays daily
Timing
Per protocol
Cycle
Long, monitored

Safety

Blood pressure monitored; used in specialized protocols.

Regulatory: Compounded.

Questions

What is VIP used for?

Primarily immune regulation and inflammation control, including use in CIRS protocols. Secondary applications include gut support and cognitive symptoms related to chronic inflammatory conditions.

How is VIP taken?

Intranasally, as a nasal spray. Each spray delivers 50 mcg. The total daily dose and number of sprays are set by the protocol.

Why does VIP require blood pressure monitoring?

VIP influences blood flow and vascular tone, so blood pressure is monitored throughout the protocol as a safety measure.

Is VIP FDA-approved?

No. VIP is a compounded preparation used in investigational and specialized clinical protocols.

How long is a VIP protocol?

Protocols are described as long and closely monitored. The duration is individualized and determined by your clinician based on your response.

Are there contraindications or exclusion criteria for VIP?

The record carries no exclusion flags for pregnancy or cancer history, but VIP is used within specialized protocols and is not appropriate as a general wellness supplement. A full clinical assessment is required.

Want a personalized protocol?

Exact dosing is set with a licensed provider in the PepDepo network. This page is education, not a prescription.

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Education only, not medical advice. Peptides discussed are for informational purposes and many are not FDA-approved. Eligibility, prescribing, compounding, and dispensing are handled by appropriately licensed entities. Exact protocols and dosing are set with a licensed provider in the PepDepo network at consult. Content is pending clinical review.