Protocol · Lose fat

Lean & Burn

The go-to stack for stubborn fat, especially around the middle.

In this protocol

Overview

Lean & Burn is designed for one purpose: attacking stubborn body fat, particularly the deep abdominal fat that resists diet and exercise alone. This stack pairs three peptides - Tesamorelin, Ipamorelin, and AOD-9604 - and each brings something the others don't. Tesamorelin is a potent GHRH analog with FDA approval for visceral fat reduction. It works by stimulating the pituitary to release growth hormone in a way that specifically targets the deep fat sitting around your organs. Ipamorelin is the workhorse GH releaser - clean, well-tolerated, and selective, meaning it triggers GH pulses without the cortisol or hunger spikes associated with older secretagogues. Together, Tesamorelin and Ipamorelin create a sustained GH environment that supports fat metabolism and body composition. AOD-9604 is a modified fragment of growth hormone that goes straight after fat breakdown without touching blood sugar - a meaningful distinction for people who are monitoring metabolic health. The schedule keeps each peptide in its ideal window. Tesamorelin and Ipamorelin are dosed nightly before bed, timed around the natural GH pulse that happens during early sleep. AOD-9604 is taken in the morning in a fasted state, when fat oxidation is already primed. What someone might notice over a course: gradual reduction in waist measurement and abdominal fullness, alongside any broader changes from improved GH signaling - better sleep quality, improved recovery. Results accumulate over weeks, not days, and the stack works best alongside consistent habits around nutrition and movement. Exact dosing, cycle length, blood sugar monitoring considerations, and any adjustments based on your labs and health history are all set with a licensed provider in the PepDepo network at your consult.

How it runs

Tesamorelin + Ipamorelin nightly before bed; AOD-9604 in the morning fasted.

Tesamorelin attacks visceral fat, Ipamorelin keeps GH pulsing cleanly, and AOD-9604 adds direct fat breakdown without affecting blood sugar.

Questions

Why does this stack use three peptides instead of one?⌄

Each one hits a different lever. Tesamorelin is specifically proven to reduce visceral fat. Ipamorelin keeps GH releasing cleanly at night without raising cortisol or hunger. AOD-9604 targets fat breakdown directly without affecting blood sugar. Combined, they cover more of the fat-loss pathway than any single peptide would.

How is this stack run day to day?⌄

Tesamorelin and Ipamorelin are injected subcutaneously each night before bed, on an empty stomach, to align with your body's natural GH pulse. AOD-9604 is injected in the morning while still fasted. The timing matters - eating around the GH injections can blunt the response.

How long does a typical course run?⌄

Tesamorelin and Ipamorelin are generally run for 3 to 6 months before reassessment. AOD-9604 runs in 8 to 12 week cycles. Your clinician will set the exact timeline based on your response and labs.

Does this affect blood sugar?⌄

Tesamorelin can affect blood sugar and is monitored at consult. AOD-9604 is specifically designed to target fat breakdown without affecting blood sugar - that's one reason it's included. Your licensed provider in the PepDepo network will review your metabolic baseline before the protocol starts.

Who should not use this stack?⌄

People with a history of cancer should not use Tesamorelin or Ipamorelin, as GH-stimulating peptides are excluded for that population. Your clinician reviews your full health history at consult before recommending any stack.

When will I see results?⌄

Peptide-based fat loss is gradual. Most people notice changes in waist measurements and abdominal firmness over the first 6 to 12 weeks, with continued progress through the full course. This is not a rapid weight-loss intervention - it's a sustained metabolic shift.

Do I need to change my diet or exercise while on this stack?⌄

The stack data does not prescribe a specific diet or exercise program, but these peptides support the fat-burning mechanisms that nutrition and movement also drive. Your clinician will give you context on how to get the most from the protocol.

Run this protocol safely

A licensed provider in the PepDepo network sets your exact protocol and dosing.

Book a consult

Education only, not medical advice. Peptides discussed are for informational purposes and many are not FDA-approved. Eligibility, prescribing, compounding, and dispensing are handled by appropriately licensed entities. Exact protocols and dosing are set with a licensed provider in the PepDepo network at consult. Content is pending clinical review.